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Review
. 2015;19(1A):A30-8.
doi: 10.5114/wo.2014.47135.

Epigenetic mechanisms of induced pluripotency

Marta Gładych  1 , Anastazja Andrzejewska  1 , Urszula Oleksiewicz  1 , Marcos R H Estécio  2
Affiliations
Review

Epigenetic mechanisms of induced pluripotency

Marta Gładych et al. Contemp Oncol (Pozn). 2015.

Abstract

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.

Keywords: DNA methylation; chromatin modifications; epigenetics; induced pluripotent stem cells.

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Figures

Fig. 1
Fig. 1
Schematic representation of the chromatin rearrangements occurring during somatic cell reprogramming and differentiation of pluripotent stem cells
Fig. 2
Fig. 2
Epigenetic modifiers responsible for chromatin reorganisation that play a role in reprogramming as drivers or blockages
See this image and copyright information in PMC

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References

    1. Robinton DA, Daley GQ. The promise of induced pluripotent stem cells in research and therapy. Nature. 2012;481:295–305. - PMC - PubMed
    1. Briggs R, King TJ. Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs’ Eggs. Proc Natl Acad Sci U S A. 1952;38:455–63. - PMC - PubMed
    1. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997;385:810–3. - PubMed
    1. Tada M, Takahama Y, Abe K, Nakatsuji N, Tada T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol. 2001;11:1553–8. - PubMed
    1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–76. - PubMed

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