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Review
. 2015;19(1A):A30-8.
doi: 10.5114/wo.2014.47135.

Epigenetic mechanisms of induced pluripotency

Marta Gładych  1 , Anastazja Andrzejewska  1 , Urszula Oleksiewicz  1 , Marcos R H Estécio  2
Affiliations
Review

Epigenetic mechanisms of induced pluripotency

Marta Gładych et al. Contemp Oncol (Pozn). 2015.

Abstract

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.

Keywords: DNA methylation; chromatin modifications; epigenetics; induced pluripotent stem cells.

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Figures

Fig. 1
Fig. 1
Schematic representation of the chromatin rearrangements occurring during somatic cell reprogramming and differentiation of pluripotent stem cells
Fig. 2
Fig. 2
Epigenetic modifiers responsible for chromatin reorganisation that play a role in reprogramming as drivers or blockages
See this image and copyright information in PMC

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