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Review
. 2015;19(1A):A44-51.
doi: 10.5114/wo.2014.47128.

Biology of renal tumour cancer stem cells applied in medicine

Damian Matak  1 , Lukasz Szymanski  2 , Cezary Szczylik  3 , Rafal Sledziewski  3 , Fei Lian  4 , Ewa Bartnik  5 , Anna Sobocinska  6 , Anna M Czarnecka  3
Affiliations
Review

Biology of renal tumour cancer stem cells applied in medicine

Damian Matak et al. Contemp Oncol (Pozn). 2015.

Abstract

The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney progenitor cells and their surface markers is compared with the role of those surface markers in ccRCC. Subsequently, we state the current hypothesis about origin of tumour-initiating cells along with their clinical and prognostic potential in RCC. Finally, we present future perspectives with respect to recent studies.

Keywords: cancer stem cells; renal cancer; tumour-initiating cells.

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Figures

Fig. 1
Fig. 1
The association of renal tumour-propagating cell markers in kidney development. Signalling pathways of kidney development is shown in green colour (frames and figures)
Fig. 2
Fig. 2
Selected molecular pathways in renal tumour-propagating cells (TPCs). A view shows relations between a number of important regulators and markers that have been implicated in biology of renal cell cancer (RCC). The functions of some of the described receptors such us CD105 and CD133 still remain not well understood but are believed to play an essential role in many physiological and pathological processes. Specific for RCC proteins HIF1/2&alpha and mTOR1/2 complex integrate crucial molecular routes taking part in tumorigenesis. Demonstrated pathways finally lead to gene expression and activation of transcription factors Oct4, SOX2, and Nanog, which are responsible for pluripotency maintenance and self-renewal of TPCs
Fig. 3
Fig. 3
The signalling pathway of renal tumour-propagating cell membrane markers and “cancer stem cell” markers
See this image and copyright information in PMC

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