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Comment
. 2015 Feb 17;42(2):203-205.
doi: 10.1016/j.immuni.2015.01.023.

The importance of cooperation: partnerless NFAT induces T cell exhaustion

Bertram Bengsch  1 , E John Wherry  2
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Free article
Comment

The importance of cooperation: partnerless NFAT induces T cell exhaustion

Bertram Bengsch et al. Immunity. .
Free article

Abstract

Downstream of costimulatory pathways, complexes of transcription factors NFAT and AP-1 promote effector T cell differentiation. In this issue of Immunity, Martinez et al. report that monomeric NFAT binding in the absence of a transcriptional partner induces a gene expression program involved in T cell exhaustion.

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  • The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
    Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. Martinez GJ, et al. Immunity. 2015 Feb 17;42(2):265-278. doi: 10.1016/j.immuni.2015.01.006. Epub 2015 Feb 10. Immunity. 2015. PMID: 25680272 Free PMC article.

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