Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Aug;45(2):304-9.

Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304)

N Dahl  1 , P Goonewardena, H Malmgren, K H Gustavson, G Holmgren, E Seemanova, G Annerén, A Flood, U Pettersson
Affiliations

Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304)

N Dahl et al. Am J Hum Genet. 1989 Aug.

Abstract

A new polymorphic DNA marker U6.2, defining the locus DXS304, was recently isolated and mapped to the Xq27 region of the X chromosome. In the previous communication we describe a linkage study encompassing 16 fragile-X families and using U6.2 and five previously described polymorphic markers at Xq26-q28. One recombination event was observed between DXS304 and the fragile-X locus in 36 informative meioses. Combined with information from other reports, our results suggest the following order of the examined loci on Xq: cen-F9-DXS105-DXS98-FRAXA-DXS304-(DXS52-F8 -DXS15). The locus DXS304 is closely linked to FRAXA, giving a peak lod score of 5.86 at a corresponding recombination fraction of .00. On the basis of the present results, it is apparent that U6.2 is a useful probe for carrier and prenatal diagnosis in fragile-X families.

PubMed Disclaimer

References

    1. Am J Med Genet. 1986 Jan-Feb;23(1-2):573-80 - PubMed
    1. Am J Med Genet. 1986 Jan-Feb;23(1-2):581-7 - PubMed
    1. Cytogenet Cell Genet. 1986;42(1-2):75-9 - PubMed
    1. N Engl J Med. 1986 Sep 4;315(10):607-9 - PubMed
    1. Lancet. 1987 Jan 31;1(8527):280 - PubMed

Publication types

Substances