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. 2015 Feb 19;5(2):61-67.
doi: 10.1007/s13659-015-0053-7. eCollection 2015 Apr.

Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity

Di-Fan Zhu #  1 , Guo-Lei Zhu #  1 , Ling-Mei Kong  1 , Ni-Man Bao  1 , Lin Zhou  1 , Yin Nian  1 , Ming-Hua Qiu  1
Affiliations

Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity

Di-Fan Zhu et al. Nat Prod Bioprospect. .

Abstract

Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2'-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2',12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5-8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC50 values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.

Keywords: 9,19-Cycloartane triterpenoids; Cimicifuga foetida; Cimilactone-type; Luciferase activity; Wnt signal pathway.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Structures of compounds 1–8
Fig. 2
Fig. 2
Inhibition of luciferase activity
Fig. 3
Fig. 3
Key 1H-1H COSY, HMBC and ROESY correlations of compound 1
See this image and copyright information in PMC

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