Randomized controlled trials 2: Analysis

Abstract

When analyzing the results of a trial the primary outcome variable must be kept in clear focus. In the analysis plan consideration must be given to comparing the characteristics of the subjects, taking account of differences in these characteristics, intention to treat analysis, interim analyses and stopping rules, mortality comparisons, composite outcomes, research design including run-in periods, factorial, stratified, and crossover designs, number needed to treat, power issues, multivariate modeling, and hypothesis-generating analyses.