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Case Reports
. 2015 Jan;4(1):62-6.
doi: 10.7453/gahmj.2014.068.

Food-specific IgG Antibody-guided Elimination Diets Followed by Resolution of Asthma Symptoms and Reduction in Pharmacological Interventions in Two Patients: A Case Report

Kulveen Virdee  1 , Jeannette Musset  2 , Matthew Baral  3 , Courtney Cronin  4 , Jeffrey Langland  5
Affiliations
Case Reports

Food-specific IgG Antibody-guided Elimination Diets Followed by Resolution of Asthma Symptoms and Reduction in Pharmacological Interventions in Two Patients: A Case Report

Kulveen Virdee et al. Glob Adv Health Med. 2015 Jan.

Abstract
in English, Chinese, Spanish

Asthma is one of the most common causes of office visits in the primary care and emergency care settings. Individuals are often able to maintain symptomatic control with long-term pharmacological therapy. Exacerbations of asthma commonly occur due to exposure to triggers such as viruses, pollutants, and allergens. While it is widely accepted that exposure to immunoglobulin E food allergens can exacerbate asthma symptoms, there is little evidence examining delayed immunoglobulin G-mediated reactions to food. Here we present two clinical cases of individuals who experienced a reduction in asthma symptoms, decreased dependence on pharmacological therapies, and increased quality of life by eliminating foods that demonstrated reactivity to immunoglobulin G levels identified through serum testing.

哮喘是初级医疗机构和急诊医疗 机构的最常见就诊疾病之一。 使 用长期药物治疗的患者通常能够 维持症状的控制。 哮喘通常会在 接触病毒、污染物和过敏原等触 发因素后加重。 虽然人们普遍认 为接触免疫球蛋白 E 食物类过敏 原可加重哮喘症状，但极少有证 据对免疫球蛋白 G 介导的迟发型 食物过敏反应进行分析。 本文介 绍了两例临床病例，他们通过杜 绝食用对免疫球蛋白 G 水平表现 出反应性的食物（由血清测试鉴 定），实现了哮喘症状的减轻， 降低了对药物治疗的依赖，并提 高了生活质量。

El asma es una de las causas más frecuentes de visita a la consulta del médico de atención primaria y a urgencias. A menudo los pacientes pueden controlar sus síntomas con tratamiento farmacológico de larga duración. Las exacerbaciones del asma ocurren por lo general debido a exposición a desencadenantes como virus, contaminantes y alérgenos. Si bien se acepta por lo general que la exposición a alérgenos alimentarios que causan la producción de inmunoglobulina E puede exacerbar los síntomas de asma, hay poca evidencia al examinar las reacciones retardadas a alimentos mediadas por inmunoglobulina G. Presentamos aquí dos casos clínicos de individuos que experimentaron una reducción de los síntomas de asma, disminución en su dependencia a tratamientos farmacológicos y una mejora en su calidad de vida eliminando alimentos que demostraron reactividad a los niveles de inmunoglobulina G identificados mediante análisis de suero.

Keywords: IgG antibody; Spasmogens; airway hyperresponsiveness; asthma; bronchodilators; case report; elimination diet; food sensitivities.

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Figures

Figure
Figure
Asthma symptom severity for Patient A. Patient self-reported severity of asthma symptoms at intake (month 0) and at subsequent visits. Scale is from 0 to 10 with 10 being the most severe.
See this image and copyright information in PMC

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