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. 2015 Mar 21;7(11):4884-9.
doi: 10.1039/c4nr06594h.

Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Michael Bradshaw  1 , Tristan D Clemons, Diwei Ho, Lucía Gutiérrez, Francisco J Lázaro, Michael J House, Timothy G St Pierre, Mark W Fear, Fiona M Wood, K Swaminathan Iyer
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Free article

Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Michael Bradshaw et al. Nanoscale. .
Free article

Abstract

This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

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