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. 2015 Mar 21;51(23):4850-3.
doi: 10.1039/c4cc09744k.

Construction of anti-parallel G-quadruplexes through sequential templated click

Romaric Bonnet  1 , Thomas Lavergne, Béatrice Gennaro, Nicolas Spinelli, Eric Defrancq
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Construction of anti-parallel G-quadruplexes through sequential templated click

Romaric Bonnet et al. Chem Commun (Camb). .

Abstract

Biologically relevant DNA sequences were assembled onto addressable cyclopeptide scaffolds through sequential oxime and CuAAc reactions. The resulting conjugates are able to fold into well-defined anti-parallel DNA G-quadruplex structures, which exhibit high stability and reduced polymorphism.

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