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. 2006 Nov;14(11):381-387.

Angiotensin II receptor antagonists (AT1-blockers, ARBs, sartans): similarities and differences

P A van Zwieten

Angiotensin II receptor antagonists (AT1-blockers, ARBs, sartans): similarities and differences

P A van Zwieten. Neth Heart J. 2006 Nov.

Abstract

A survey is presented of the registered non-peptidergic angiotensin II receptor antagonists (AT1 blockers, ARBs, sartans) and their general properties and similarities. Accordingly, their receptor profile, pharmacokinetic and therapeutic applications are discussed. In addition, attention is paid to the individual characteristics of the AT1 blockers now available. A few components of this category offer additional potentially beneficial properties, owing to their pharmacological or metabolic characteristics. Such additional properties are critically discussed for eprosartan, losartan, telmisartan and valsartan.

Keywords: AT1 receptors; angiotensin II receptor antagonists; insulin sensitisation; renin-angiotensin system.

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