Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015;15(9):886-93.
doi: 10.2174/1568026615666150220120651.

Anti-inflammatory and antioxidant properties of Piper species: a perspective from screening to molecular mechanisms

Sarvesh Kumar, Shashwat Malhotra, Ashok K Prasad, Erik V Van der Eycken, Marc E Bracke, William G Stetler-Stevenson, Virinder S Parmar, Balaram Ghosh  1
Affiliations
Review

Anti-inflammatory and antioxidant properties of Piper species: a perspective from screening to molecular mechanisms

Sarvesh Kumar et al. Curr Top Med Chem. 2015.

Abstract

Identifying novel therapeutic agents from natural sources and their possible intervention studies has been one of the major areas in biomedical research in recent years. Piper species are highly important - commercially, economically and medicinally. Our groups have been working for more than two decades on the identification and characterization of novel therapeutic lead molecules from Piper species. We have extensively studied the biological activities of various extracts of Piper longum and Piper galeatum, and identified and characterized novel molecules from these species. Using synthetic chemistry, various functional groups of the lead molecules were modified and structure activity relationship (SAR) studies identified synthetic molecules with better efficacy and lower IC50 values. Moreover, the mechanisms of actions of some of these molecules were studied at the molecular level. The objective of this review is to summarize experimental data published from our laboratories and others on antioxidant and anti-inflammatory potentials of Piper species and their chemical constituents.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

The authors confirm that this article content has no conflict of interest.

Figures

Fig. (1).
Fig. (1).
Structures of identified potent inhibitors of cell adhesion molecules (CAMs).
Scheme 1.
Scheme 1.
Synthesis of ETMC and ETMTC(source: Biochemistry, 2005. 44(48): p. 15944–52; Eur J Med Chem, 2011. 46(11): p. 5498–511).
See this image and copyright information in PMC

References

    1. Duke JA Medicinal plants. Science, 1985. 229(4718): p. 1036, 1038. - PubMed
    1. Singh N; Kumar S; Singh P; Raj HG; Prasad AK; Parmar VS; Ghosh B Piper longum Linn. Extract inhibits TNF-alpha-induced expression of cell adhesion molecules by inhibiting NF-kappaB activation and microsomal lipid peroxidation. Phytomedicine, 2008. 15(4): p. 284–91. - PubMed
    1. Chonpathompikunlert P; Wattanathorn J; Muchimapura S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease. Food Chem. Toxicol, 2010. 48(3): p. 798–802. - PubMed
    1. Prasad Ashok, K.; Kumar Vineet; Arya1 Pragya; Kumar Sarvesh; Dabur Rajesh; Singh Naresh; Chhillar Anil, K.; Gainda L; Sharma; Ghosh Balaram; Wenge Jesper; Olsen Carl, E.; Parmar Virinder,S.. Investigations toward new lead compounds from medicinally important plants. Pure and Applied Chem, 2005. 77(1): p. 25–40.
    1. Gounder R Kava consumption and its health effects. Pac Health Dialog, 2006. 13(2): p. 131–5. - PubMed

Publication types

MeSH terms