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Review
. 2015 Aug;3(3):201-8.
doi: 10.1093/gastro/gov004. Epub 2015 Feb 18.

Hypergastrinemia

Sunil Dacha  1 , Mohammed Razvi  2 , Julia Massaad  2 , Qiang Cai  2 , Mohammad Wehbi  2
Affiliations
Review

Hypergastrinemia

Sunil Dacha et al. Gastroenterol Rep (Oxf). 2015 Aug.

Abstract

Gastrin is an important hormone of the digestive system, which assists gastric acid secretion. It may be pathologically elevated in conditions such as Zollinger-Ellison syndrome, or due to common medications such as proton pump inhibitors. In this review we provide an overview of the pathophysiology and medical causes of hypergastrinemia, diagnostic testing and clinical consequences of chronic hypergastrinemia.

Keywords: carcinoid; helicobacter pylori; hypergastrinemia.

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Figures

Figure 1.
Figure 1.
Physiology of gastric acid secretion. Histamine, acetylcholine and gastrin effect on gastric acid secretion is shown (Reference: Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacology, 11th edition. http://www.accessmedicine.com).
See this image and copyright information in PMC

References

    1. Burkitt MD, Varro A, Pritchard DM. Importance of gastrin in the pathogenesis and treatment of gastric tumors. World J Gastroenterol 2009;15:1–16. - PMC - PubMed
    1. Berna MJ, Hoffman KM, Serrano J, et al. Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. Medicine (Baltimore) 2006;85:295–330. - PMC - PubMed
    1. Mortensen NJ. The anatomy of the gastrin cell. Ann R Coll Surg Engl 1980;62:462–9. - PMC - PubMed
    1. Waldum HL, Fossmark R, Bakke I, et al. Hypergastrinemia in animals and man: causes and consequences. Scand J Gastroenterol 2004;39:505–9. - PubMed
    1. Peghini PL, Annibale B, Azzoni C, et al. Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas. Gastroenterology 2002;123:68–85. - PubMed