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. 1989 Jul 3;491(1):185-8.
doi: 10.1016/0006-8993(89)90103-0.

Feline subthalamic nucleus neurons contain glutamate-like but not GABA-like or glycine-like immunoreactivity

R L Albin  1 , J W Aldridge, A B Young, S Gilman
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Free article

Feline subthalamic nucleus neurons contain glutamate-like but not GABA-like or glycine-like immunoreactivity

R L Albin et al. Brain Res. .
Free article

Abstract

The identity of the neurotransmitter of subthalamic nucleus neurons has not been definitively established. GABA, glycine, and glutamate have all been hypothesized to be the neurotransmitter of these neurons. Immunohistochemistry with 3 well characterized antisera against glutamate, GABA, and glycine were used to study feline subthalamic nucleus neurons. These neurons were found to contain intense glutamate-like but not GABA- or glycine-like immunoreactivity. The surrounding neuropil contained glutamate-like and GABA-like but not glycine-like immunoreactivity. These results support the hypothesis that subthalamic nucleus neurons are glutamatergic.

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