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Comment
. 2015 Feb 19;57(4):573-574.
doi: 10.1016/j.molcel.2015.02.005.

A new path to leukemia with WIT

Jose Luis Sardina  1 , Thomas Graf  2
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Comment

A new path to leukemia with WIT

Jose Luis Sardina et al. Mol Cell. .
Free article

Abstract

In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three genes inducing myeloid cell proliferation.

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