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Clinical Trial
. 1989 Sep 9;2(8663):591-3.
doi: 10.1016/s0140-6736(89)90714-9.

Effects of UK 69 578: a novel atriopeptidase inhibitor

D B Northridge  1 , A G Jardine, C T Alabaster, P L Barclay, J M Connell, H J Dargie, S G Dilly, I N Findlay, A F Lever, G M Samuels
Affiliations
Clinical Trial

Effects of UK 69 578: a novel atriopeptidase inhibitor

D B Northridge et al. Lancet. .

Abstract

UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.

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