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Review
. 2015 Sep;23(Pt A):101-15.
doi: 10.1016/j.arr.2015.02.003. Epub 2015 Feb 19.

Quality control systems in cardiac aging

Ellen K Quarles  1 , Dao-Fu Dai  2 , Autumn Tocchi  3 , Nathan Basisty  4 , Lemuel Gitari  5 , Peter S Rabinovitch  6
Affiliations
Review

Quality control systems in cardiac aging

Ellen K Quarles et al. Ageing Res Rev. 2015 Sep.

Abstract

Cardiac aging is an intrinsic process that results in impaired cardiac function, along with cellular and molecular changes. These degenerative changes are intimately associated with quality control mechanisms. This review provides a general overview of the clinical and cellular changes which manifest in cardiac aging, and the quality control mechanisms involved in maintaining homeostasis and retarding aging. These mechanisms include autophagy, ubiquitin-mediated turnover, apoptosis, mitochondrial quality control and cardiac matrix homeostasis. Finally, we discuss aging interventions that have been observed to impact cardiac health outcomes. These include caloric restriction, rapamycin, resveratrol, GDF11, mitochondrial antioxidants and cardiolipin-targeted therapeutics. A greater understanding of the quality control mechanisms that promote cardiac homeostasis will help to understand the benefits of these interventions, and hopefully lead to further improved therapeutic modalities.

Keywords: Aging; Cardiac function; Heart; Proteostasis; Quality control.

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