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. 2015:9:15-8.
doi: 10.1016/j.ijscr.2015.02.014. Epub 2015 Feb 11.

Actinomyces-induced inflammatory myofibroblastic tumor of the colon: A rare cause of an abdominal mass: Akbulut et al. inflammatory myofibroblastictumor due to actinomyces spp

Sami Akbulut  1 , Yusuf Yagmur  2 , Serdar Gumus  2 , Nilgun Sogutcu  2 , Firat Demircan  2
Affiliations

Actinomyces-induced inflammatory myofibroblastic tumor of the colon: A rare cause of an abdominal mass: Akbulut et al. inflammatory myofibroblastictumor due to actinomyces spp

Sami Akbulut et al. Int J Surg Case Rep. 2015.

Abstract

Introduction: Inflammatory myofibroblastic tumors (IMFTs) are neoplastic lesions that are either benign or have low-grade malignancy potential. Although the etiopathogenesis is not entirely clear, many factors play a role in their development, including trauma, autoimmune disorders, and infectious and inflammatory processes. However, IMFTs caused by Actinomyces spp. infection are rare, with a limited number of cases reported in the literature.

Presentation of case: A 30-year-old woman was admitted to our clinic with abdominal pain and a palpable abdominal mass. Contrast-enhanced computed tomography revealed a tumoral lesion (11×10×7cm) in the right colon. A right hemicolectomy and ileocolic anastomosis were performed, during which almost complete obstruction of the lumen by the 7.5×7.0×5.0cm tumor was observed. Histopathology and immunohistochemical findings revealed that the tumor was consistent with an IMFT that developed from an Actinomyces infection. The patient was then placed on amoxicillin and doxycycline therapy.

Conclusion: This case demonstrates that the development of IMFT secondary to actinomycosis is difficult to predict in the preoperative period. Once an exact diagnosis is confirmed by histopathologic examination, affected patients should receive prolonged antibiotherapy.

Keywords: Actinomycosis; Colon; Immunhistochemical stain; Inflammatory myofibroblastic tumor.

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Figures

Fig. 1
Fig. 1
Contrast-enhanced abdominal tomography. Marked mural thickening was observed in the terminal ileum and colon segment, and neighboring mesentery and pericolic fatty tissue had a heterogeneous appearance. An 11 × 10 × 7 cm isodense mass was seen in the ascending colon.
Fig. 2
Fig. 2
Histopathology of the tumor. Hematoxylin and eosin staining revealed (A) bland fusiform elements arranged in fascicules, with (B) lymphocytes, plasma cells, and eosinophils, indicative of an inflammatory myofibroblastic tumor. (C) The bland fusiform elements of the tumor contained Actinomyces (basophilic clusters of bacteria with a peripheral, more eosinophilic zone of radiating filaments surrounded by acute inflammation) (A: 100 × ; B: 200 × ; C: 100 × ).
Fig. 3
Fig. 3
Immunohistochemical analysis. The tumor cells were immunopositive for vimentin (100 × ).
See this image and copyright information in PMC

References

    1. Yagmur Y., Akbulut S., Gumus S. Mesenteric inflammatory pseudotumor: a case report and comprehensive literature review. J. Gastrointest. Cancer. 2014;45(4):414–420. - PubMed
    1. Das N., Lee J., Madden M., Elliot C.S., Bateson P., Gilliland R. A rare case of abdominal actinomycosis presenting as an inflammatory pseudotumour. Int. J. Colorectal. Dis. 2006;21(5):483–484. - PubMed
    1. Evans J., Chan C., Gluch L., Fielding I., Eckstein R. Inflammatory pseudotumour secondary to actinomyces infection. Aust. N. Z. J. Surg. 1999;6:467–469. - PubMed
    1. Radhi J., Hadjis N., Anderson L., Burbridge B., Ali K. Retroperitoneal actinomycosis masquerading as inflammatory pseudotumor. J. Pediatr. Surg. 1997;32(4):618–620. - PubMed
    1. Yang X.X., Lin J.M., Xu K.J., Wang S.Q., Luo T.T., Geng X.X., Huang R.G., Jiang N. Hepatic actinomycosis: report of one case and analysis of 32 previously reported cases. World J. Gastroenterol. 2014;20(43):16372––16376. - PMC - PubMed