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Review
. 2015 Feb;32(2):182-92.
doi: 10.1016/j.rmr.2014.08.014. Epub 2014 Nov 6.

[Targeted therapies in non-small cell lung cancer in 2014]

[Article in French]
C Leduc  1 , B Besse  2
Affiliations
Review

[Targeted therapies in non-small cell lung cancer in 2014]

[Article in French]
C Leduc et al. Rev Mal Respir. 2015 Feb.

Abstract

For several years, the identification of molecular sequencing alterations has considerably changed the perception and treatment of non-small cell lung cancer (NSCLC). These alterations have been defined as "driver mutations", such as mutations in EGFR and EML4-ALK fusion gene, and are highly sensitive to specific therapies. Other targets have also been identified recently. Personalized medicine is now a reality for patients with advanced NSCLC on the basis of routine screening for EGFR, HER2, KRAS, BRAF, PI3KCA mutations and EML4-ALK rearrangement. This article describes identified biomarkers, available targeted therapies, and the main clinical research approaches in NSCLC.

Keywords: Biomarkers; Biomarqueurs; Cancer bronchique non à petites cellules; Lung cancer; Targeted therapy; Thérapies ciblées.

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