Alcohol-induced blackouts and maternal family history of problematic alcohol use

Abstract

Background: Consequences of heavy drinking include alcohol-induced blackouts, which are periods of amnesia for all or part of a drinking event. One risk factor for blackouts is family history of problematic alcohol use (FH+); however, research rarely distinguishes maternal from paternal FH+. The objective of this study was to examine whether maternal or paternal FH+ better predicts likelihood of experiencing blackouts than a general measure of overall FH+, and whether gender moderates this association.

Method: Participants (N=1164; 65.4% are female) were first-time college freshmen (age range=17-19) who participated in a 6-year, 10-assessment, longitudinal study in the United States. Alcohol-induced blackouts, the dependent measure, were dichotomized (yes/no) based on endorsement of memory problems after drinking using a single item during Years 4-6. FH+, captured at baseline, was coded if participants self-reported that their mother, father, or any of their four grandparents were a possible or definite problem drinker.

Results: Overall, 773 (66.4%) participants reported experiencing blackouts during Years 4-6. Women were more likely to report blackouts than men; however, compared with women with a maternal FH+, men with a maternal FH+ were more than twice as likely to report blackouts.

Discussion: Men appear to be more susceptible than women to the effects of a maternal FH+. Genetic and environmental explanations for this finding are discussed. In sum, these findings are an important step toward understanding a significant yet understudied negative consequence of heavy alcohol use.

Keywords: Alcohol; Blackout; Family history; Gender; Memory.