Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:574186.
doi: 10.1155/2015/574186. Epub 2015 Feb 1.

Is there a persistent dysfunction of neurovascular coupling in migraine?

Andrej Fabjan  1 , Marjan Zaletel  2 , Bojana Žvan  2
Affiliations
Review

Is there a persistent dysfunction of neurovascular coupling in migraine?

Andrej Fabjan et al. Biomed Res Int. 2015.

Abstract

Changes in cerebral blood flow are one of the main features of migraine attack and have inspired the vascular theory of migraine. This traditional view has been reshaped with recent experimental data, which gave rise to the neural theory of migraine. In this review, we speculate that there might be an important link between the two theories, that is, the dysfunction of neurovascular coupling.

PubMed Disclaimer

References

    1. Shevel E. The extracranial vascular theory of migraine—a great story confirmed by the facts. Headache. 2011;51(3):409–417. doi: 10.1111/j.1526-4610.2011.01844.x. - DOI - PubMed
    1. Noseda R., Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013;154(supplement 1):S44–S53. doi: 10.1016/j.pain.2013.07.021. - DOI - PubMed
    1. Lambert G. A., Zagami A. S. The mode of action of migraine triggers: a hypothesis. Headache. 2009;49(2):253–275. doi: 10.1111/j.1526-4610.2008.01230.x. - DOI - PubMed
    1. Coppola G., Pierelli F., Schoenen J. Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia. 2007;27(12):1429–1439. doi: 10.1111/j.1468-2982.2007.01500.x. - DOI - PubMed
    1. Diener H. C., May A. New aspects of migraine pathophysiology: lessons learned from positron emisson tomography. Current Opinion in Neurology. 1996;9(3):199–201. doi: 10.1097/00019052-199606000-00007. - DOI - PubMed

MeSH terms

LinkOut - more resources