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Clinical Trial
. 2015:2015:870987.
doi: 10.1155/2015/870987. Epub 2015 Jan 29.

Strategy for the management of macular edema in retinal vein occlusion: the European VitreoRetinal Society macular edema study

Ron A Adelman  1 , Aaron J Parnes  2 , Silvia Bopp  3 , Ihab Saad Othman  4 , Didier Ducournau  5
Affiliations
Clinical Trial

Strategy for the management of macular edema in retinal vein occlusion: the European VitreoRetinal Society macular edema study

Ron A Adelman et al. Biomed Res Int. 2015.

Erratum in

Abstract

Objective: To compare the efficacy of different therapies in the treatment of macular edema associated with retinal vein occlusion (RVO).

Design: This is a nonrandomized, multicenter collaborative study.

Participants: 86 retina specialists from 29 countries provided clinical information, including choice of treatment and outcome, on 2,603 patients with macular edema including 738 cases of RVO.

Methods: Reported data included the type and number of treatments performed, visual acuities, and other clinical and diagnostic findings.

Main outcome measures: The mean increase in visual acuity and mean number of treatments performed.

Results: 358 cases of central retinal vein occlusion (CRVO) and 380 cases of branch retinal vein occlusion (BRVO) were included in this investigation. Taking all RVO cases together, pars plana vitrectomy with internal limiting membrane (ILM) peeling alone resulted in an improvement in vision greater than other therapies. Those treated with intravitreal antivascular endothelial growth factor (anti-VEGF) injection alone showed the second greatest improvement in vision. Dexamethasone intravitreal implant alone and intravitreal triamcinolone alone both resulted in modest visual gains.

Conclusions: In the treatment of macular edema in RVO, vitrectomy with ILM peeling may achieve visual improvement and may be a good option for certain cases. Anti-VEGF injection is the most effective of the nonsurgical treatments.

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Figures

Figure 1
Figure 1
CRVO is central retinal vein occlusion, PPV is pars plana vitrectomy, ILM is internal limiting membrane, and VEGF is vascular endothelial growth factor.
Figure 2
Figure 2
BRVO is branch retinal vein occlusion, PPV is pars plana vitrectomy, ILM is internal limiting membrane, and VEGF is vascular endothelial growth factor.
Figure 3
Figure 3
RVO is retinal vein occlusion, PPV is pars plana vitrectomy, ILM is internal limiting membrane, and VEGF is vascular endothelial growth factor.
Figure 4
Figure 4
RVO is retinal vein occlusion and VEGF is vascular endothelial growth factor.
Figure 5
Figure 5
RVO is retinal vein occlusion, PPV is pars plana vitrectomy, ILM is internal limiting membrane, and VEGF is vascular endothelial growth factor.
See this image and copyright information in PMC

References

    1. Rogers S., McIntosh R. L., Cheung N., et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313.e1–319.e1. doi: 10.1016/j.ophtha.2009.07.017. - DOI - PMC - PubMed
    1. McIntosh R. L., Rogers S. L., Lim L., et al. Natural history of central retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010;117(6):1113.e15–1123.e15. doi: 10.1016/j.ophtha.2010.01.060. - DOI - PubMed
    1. Rogers S. L., McIntosh R. L., Lim L., et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010;117(6):1094.e5–1101.e5. doi: 10.1016/j.ophtha.2010.01.058. - DOI - PubMed
    1. The Central Vein Occlusion Study Group. Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion. Ophthalmology. 1995;102(10):1425–1433. doi: 10.1016/S0161-6420(95)30849-4. - DOI - PubMed
    1. Argon laser photocoagulation for macular edema in branch vein occlusion. The American Journal of Ophthalmology. 1984;98:271–282. - PubMed

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