Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Aug;28(2):155-9.
doi: 10.1111/j.1365-2125.1989.tb05408.x.

Neuromuscular blockade with vecuronium in paediatric patients with burn injury

A K Mills  1 , J A Martyn
Affiliations

Neuromuscular blockade with vecuronium in paediatric patients with burn injury

A K Mills et al. Br J Clin Pharmacol. 1989 Aug.

Abstract

1. The effect of body surface area (BSA) burn injury on neuromuscular pharmacodynamics of vecuronium was evaluated. 2. The neuromuscular responses of 15 burned children were compared with those in five controls. 3. The effective dose for 50% suppression of twitch tension (ED50) was 34 micrograms kg-1 for patients with less than 40% BSA burn, 55 micrograms kg-1 for 40-60% BSA burn, and 65 micrograms kg-1 for patients with greater than 60% BSA burn. These values were significantly higher than the value for control patients, which was 18 micrograms kg-1. 4. Burn injury induces a resistance to the neuromuscular effects of vecuronium, the magnitude of which is related to burn size.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Life Sci. 1988;43(1):35-40 - PubMed
    1. Clin Pharmacol Ther. 1988 Mar;43(3):250-5 - PubMed
    1. J Appl Physiol (1985). 1988 Oct;65(4):1655-61 - PubMed
    1. Anesthesiology. 1975 Jul;43(1):89-99 - PubMed
    1. Can Anaesth Soc J. 1979 Nov;26(6):489-91 - PubMed

Publication types

Substances