Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb 23;10(2):e0117474.
doi: 10.1371/journal.pone.0117474. eCollection 2015.

Factors affecting cerebral oxygenation in hemodialysis patients: cerebral oxygenation associates with pH, hemodialysis duration, serum albumin concentration, and diabetes mellitus

Kiyonori Ito  1 , Susumu Ookawara  2 , Yuichiro Ueda  1 , Sawako Goto  1 , Haruhisa Miyazawa  1 , Hodaka Yamada  3 , Taisuke Kitano  1 , Mitsunobu Shindo  1 , Yoshio Kaku  1 , Keiji Hirai  1 , Masashi Yoshida  3 , Taro Hoshino  1 , Aoi Nabata  1 , Honami Mori  1 , Izumi Yoshida  1 , Masafumi Kakei  3 , Kaoru Tabei  1
Affiliations

Factors affecting cerebral oxygenation in hemodialysis patients: cerebral oxygenation associates with pH, hemodialysis duration, serum albumin concentration, and diabetes mellitus

Kiyonori Ito et al. PLoS One. .

Abstract

Background: Patients undergoing hemodialysis (HD) often develop cerebral disease complications. Furthermore, cerebral regional saturation of oxygen (rSO2) was previously reported to be significantly lower in HD patients than in healthy subjects. We aimed to identify the factors affecting the cerebral rSO2 in HD patients.

Methods: Fifty-four HD patients (38 men and 16 women; mean age, 67.7 ± 1.2 years, HD duration, 6.5 ± 1.9 years) were recruited. Cerebral rSO2 was monitored at the forehead before HD using an INVOS 5100C (Covidien Japan, Tokyo, Japan).

Results: The rSO2 levels were significantly lower in HD patients compared with healthy controls (49.5 ± 1.7% vs. 68.9 ± 1.6%, p <0.001). Multiple regression analysis showed that cerebral rSO2 independently associated with pH (standardized coefficient: -0.35), HD duration (standardized coefficient: -0.33), and serum albumin concentration (standardized coefficient: 0.28). Furthermore, the rSO2 was significantly lower in HD patients with diabetes mellitus (DM), compared with patients without DM (46.8 ± 1.7% vs. 52.1 ± 1.8%, p <0.05).

Conclusions: In HD patients, cerebral rSO2 was affected by multiple factors, including pH, HD duration, and serum albumin concentration. Furthermore, this is the first report describing significantly lower levels of rSO2 in HD patients with DM than in those without DM.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Comparison between cerebral rSO2 in hemodialysis patients and healthy controls.
Fig 2
Fig 2. Comparison of cerebral rSO2 in hemodialysis patients (HD) with and without diabetes mellitus (DM).
* < 0.05 at HD patients with DM vs. those without DM.
Fig 3
Fig 3. Correlation between hemodialysis duration and rSO2.
See this image and copyright information in PMC

References

    1. Prohovnik I, Post J, Uribarri J, Lee H, Sandu O, et al. (2007) Cerebrovascular effects of hemodialysis in chronic kidney disease. J Cereb Blood Flow Metab 27: 1861–1869. - PubMed
    1. Nakai S, Watanabe Y, Masakane I, Wada A, Shoji T, et al.(2013) Overview of regular dialysis treatment in Japan (as of 31 December 2011). Ther Apher Dial 17: 567–611. 10.1111/1744-9987.12147 - DOI - PubMed
    1. Naganuma T, Uchida J, Tsuchida K, Takemoto Y, Tatsumi S, et al. (2005) Silent cerebral infarction predicts vascular events in hemodialysis patients. Kidney Int 67: 2434–2439. - PubMed
    1. Parnia S, Nasir A, Ahn A, Malik H, Yang J, et al. (2014) A feasibility study of cerebral oximetry during in-hospital mechanical and manual cardiopulmonary resuscitation. Crit Care Med 42: 930–933. 10.1097/CCM.0000000000000047 - DOI - PubMed
    1. Ono M, Arnaoutakis GJ, Fine DM, Brady K, Easley RB, et al. (2013) Blood pressure excursions below the cerebral autoregulation threshold during cardiac surgery are associated with acute kidney injury. Crit Care Med 41: 464–471. 10.1097/CCM.0b013e31826ab3a1 - DOI - PMC - PubMed