Comparison of retinal thicknesses measured using swept-source and spectral-domain optical coherence tomography devices

Abstract

Background and objective: To compare retinal thicknesses measured using swept-source optical coherence tomography (SS-OCT) and spectral-domain (SD) OCT devices.

Patients and methods: In a cohort study of 76 healthy eyes and 21 eyes with high myopia, mean retinal thicknesses in ETDRS subfields were compared between OCT scans obtained from the Topcon DRI OCT-1 (Topcon, Tokyo, Japan), Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany), and Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA).

Results: Central retinal thickness measurements differed significantly among the three OCT devices (Spectralis: 271 µm; Cirrus: 254 µm; DRI OCT-1: 238 µm; P < .001), with mean differences ranging from 15.6 µm to 37 µm. Intraclass correlation coefficients were at least 0.94 for any pair of machines. Similar results were observed in all nine ETDRS subfields. In all sectors, retinal thickness measurements obtained using the 3-D and radial scans of the SS-OCT were similar (mean differences: 0.7 to 3.8 µm).

Conclusion: Retinal thickness measurements obtained from DRI OCT-1 and SD-OCT are different and should be accounted for when comparing results of OCT scans from different devices.