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. 2015 Jun;67(6):1678-80.
doi: 10.1002/art.39090.

Induction of Osteoarthritis-like Pathologic Changes by Chronic Alcohol Consumption in an Experimental Mouse Model

Ranjan Kc  1 , Robin Voigt  1 , Xin Li  1 , Christopher B Forsyth  1 , Michael B Ellman  1   2 , Keith C Summa  3 , Fred W Turek  3 , Ali Keshavarzian  1   4 , Jae-Sung Kim  5 , Hee-Jeong Im  1   6
Affiliations

Induction of Osteoarthritis-like Pathologic Changes by Chronic Alcohol Consumption in an Experimental Mouse Model

Ranjan Kc et al. Arthritis Rheumatol. 2015 Jun.
No abstract available

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Conflict of interest statement

COMPETING INTERESTS

The authors declare that there is no competing interest.

Figures

Figure 1
Figure 1. Chronic ethanol consumption induces pathological changes in articular cartilage
Knee joints and glenohumeral joints (n=10 per group) were serially sectioned in a sagittal plane, and 3–4 representative midsagittal 7-μm-thick sections were selected and stained with Safranin-O for histological evaluation. A, Control-diet mice demonstrate normal architecture of articular cartilage with intense Safranin O staining. However, alcohol-fed mice show OA-like changes with reduction of Safranin O staining indicating depletion of PG and higher OARSI score compared to control group. Left panel is low magnification (4X), right panel high magnification (20X). B, Alcohol-fed mice display PG depletion and an irregular cartilage surface (arrows) in shoulder joints with significantly increased OA severity score. Results are expressed as mean ± SD (n=10); *, p < 0.05 vs control-diet mice. C, No difference is seen in spine discs of alcohol-fed mice compared to the control group. Scale bars =50μm
See this image and copyright information in PMC

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