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. 2014 Dec;19(12):1124-8.

Comparison of the effect of betamethasone versus dexamethasone on the amniotic fluid index in the women at risk of preterm labor

Hatav Ghasemi Tehrani  1 , Behnaz Khani  1 , Zahra Komrani  1
Affiliations

Comparison of the effect of betamethasone versus dexamethasone on the amniotic fluid index in the women at risk of preterm labor

Hatav Ghasemi Tehrani et al. J Res Med Sci. 2014 Dec.

Abstract

Background: The aim of this study was to compare the biophysical profile parameters (BPP), especially amniotic fluid index (AFI), before and after administration of corticosteroids (dexamethasone and betamethasone) and these two groups with each other.

Materials and methods: This double-blind clinical trial study was done on 70 patients for 28-34 weeks women having at least one preterm labor in their previous pregnancy has been submitted in Al Zahra and Shahid Beheshti clinic in 2012-2013. 70 women were randomly allocated in two groups. The first group were received 8 mg each 12 h for 4 doses dexamethasone when the patient at risk of preterm labor admitted in clinic or hospitalized and the second group were received 12 mg betamethasone each 24 h similarly. Nonstress test (NST) and BPP and sonography AFI were done in all cases, and then NST was done in the before and 3 days after intervention. Data were analyzed by SPSS software version 20 using t-test, Chi-square, and Fisher's test.

Results: There was no significant difference between the range of AFI before and after the drug intervention (P > 0.05). Two groups had no significant difference in AFI before and after administration of corticosteroids. No significant difference was seen in NST acceleration tests between the two groups before and after corticosteroids administration.

Conclusion: Biophysical profile had a significant difference in dexamethasone group respect to that of betamethasone group. Furthermore, the biophysical profile had a significant difference before and after the administration of corticosteroids in two groups. It is noted that AFI had no role in this matter.

Keywords: Amniotic fluid index; betamethasone; biophysical profile; dexamethasone; preterm labor.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Amniotic fluid index changes in the before and after intervention between the two groups
See this image and copyright information in PMC

References

    1. Hass DM. Ante natal coritcosteroid for fetal lung development. BMJ Clin Evid. 2010;11:55–9.
    1. Petrozella LN, Dashe JS, McIntire DD, Leveno KJ. Clinical significance of borderline amniotic fluid index and oligohydramnios in preterm pregnancy. Obstet Gynecol. 2011;117:338–42. - PubMed
    1. Abbasalizadeh S, Pharabar ZN, Abbasalizadeh F, Ghojazadeh M, Goldust M. Efficacy of betamethasone on the fetal motion and biophysical profile and amniotic fluid index in preterm fetuses. Pak J Biol Sci. 2013;16:1569–73. - PubMed
    1. Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment after the first week of life for bronchopulmonary dysplasia in preterm infants: A systematic review. Neonatology. 2010;98:289–96. - PubMed
    1. Khandelwal M, Chang E, Hansen C, Hunter K, Milcarek B. Betamethasone dosing interval:12 or 24 hours apart? A randomized, noninferiority open trial. Am J Obstet Gynecol. 2012;206:201.e1–11. - PubMed