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. 2015 Mar 6;80(5):2907-11.
doi: 10.1021/acs.joc.5b00135. Epub 2015 Feb 25.

Engaging nonaromatic, heterocyclic tosylates in reductive cross-coupling with aryl and heteroaryl bromides

Gary A Molander  1 , Kaitlin M Traister, Brian T O'Neill
Affiliations

Engaging nonaromatic, heterocyclic tosylates in reductive cross-coupling with aryl and heteroaryl bromides

Gary A Molander et al. J Org Chem. .

Abstract

A method has been developed for the introduction of nonaromatic heterocyclic structures onto aryl and heteroaryl bromides using alkyl tosylates in a reductive cross-coupling manifold. This protocol offers an improvement over previous methods by utilizing alkyl tosylate coupling partners that are bench-stable, crystalline solids that can be prepared from inexpensive, commercially available alcohols.

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