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. 2015 May;59(5):2926-9.
doi: 10.1128/AAC.05072-14. Epub 2015 Feb 23.

Persistence of vancomycin resistance in multiple clones of Enterococcus faecium isolated from Danish broilers 15 years after the ban of avoparcin

Valeria Bortolaia  1 , Manuela Mander  2 , Lars B Jensen  3 , John E Olsen  2 , Luca Guardabassi  2
Affiliations

Persistence of vancomycin resistance in multiple clones of Enterococcus faecium isolated from Danish broilers 15 years after the ban of avoparcin

Valeria Bortolaia et al. Antimicrob Agents Chemother. 2015 May.

Abstract

The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a transferable nontypeable plasmid lineage occurring in multiple E. faecium clones. Coselection of sequence type 842 by tetracycline use only partly explained the persistence of vancomycin resistance in the absence of detectable plasmid coresistance and toxin-antitoxin systems.

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Figures

FIG 1
FIG 1
Geographical distribution of Danish broiler flocks positive for vancomycin-resistant Enterococcus faecium. Numbers represent sequence types (STs), and identical STs are indicated by the same color.
See this image and copyright information in PMC

References

    1. Bortolaia V, Guardabassi L. 2014. Zoonotic transmission of antimicrobial resistant enterococci: a threat to public health or an overemphasised risk? p 407–431. In Sing A. (ed), Zoonoses—infections affecting humans and animals. Springer, Dordrecht, Netherlands.
    1. Lester C, Frimodt-Møller N, Sørensen TL, Monnet DL, Hammerum AM. 2006. In vivo transfer of the vanA resistance gene from an Enterococcus faecium isolate of animal origin to an E. faecium isolate of human origin in the intestines of human volunteers. Antimicrob Agents Chemother 50:596–599. doi:10.1128/AAC.50.2.596-599.2006. - DOI - PMC - PubMed
    1. Sletvold H, Johnsen PJ, Wikmark OG, Simonsen GS, Sundsfjord A, Nielsen KM. 2010. Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages. J Antimicrob Chemother 65:1894–1906. doi:10.1093/jac/dkq219. - DOI - PMC - PubMed
    1. Hammerum AM, Heuer OE, Lester CH, Agersø Y, Seyfarth AM, Emborg HD, Frimodt-Møller N, Monnet DL. 2007. Comment on: withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health. Int J Antimicrob Agents 30:466–468. doi:10.1016/j.ijantimicag.2007.07.012. - DOI - PubMed
    1. Danish Institute for Food and Veterinary Research. 2011. DANMAP: the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme 2010. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food, animals and humans in Denmark. Danish Institute for Food and Veterinary Research, Copenhagen, Denmark.

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