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. 2015 Feb;8(1):79-81.
doi: 10.1093/ckj/sfu134. Epub 2014 Dec 13.

Renal denervation of the native kidneys for drug-resistant hypertension after kidney transplantation

Linn C Dobrowolski  1 , Frederike J Bemelman  1 , Ineke J M Ten Berge  1 , Bert-Jan H van den Born  2 , Jim A Reekers  3 , C T Paul Krediet  1
Affiliations

Renal denervation of the native kidneys for drug-resistant hypertension after kidney transplantation

Linn C Dobrowolski et al. Clin Kidney J. 2015 Feb.

Abstract

There is a strong rationale for renal denervation (RDN) of the native kidneys in kidney transplant recipients with treatment-resistant hypertension. We present a patient with a stable graft function, who underwent RDN for posttransplant therapy-resistant hypertension (24-h ambulatory blood pressure measurement (ABPM) 143/89 mmHg, while compliantly using five different antihypertensive agents). After RDN, BP measurements and orthostatic complaints required withdrawal of two antihypertensive agents and halving a third. At 6 months, ABPM was 134/84 mmHg and allograft function remained unchanged. This case calls for designing well-designed prospective studies on RDN in kidney transplant recipients.

Keywords: kidney transplantation; renal denervation.

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Figures

Fig. 1.
Fig. 1.
Renal denervation of the native left kidney. The arrow points the tip of the radiofrequency ablation catheter. Filling of the renal arteries with contrast-agent is shown; however no filling of intrarenal parenchymal vessels is visualized.
Fig. 2.
Fig. 2.
Results of the 24-h ambulatory blood pressure measurement (ABPM). The ABPM after RDN was recorded while the patient had discontinued two antihypertensive agents and one drug dosage was reduced to 50%.
See this image and copyright information in PMC

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