Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Mar;38(3):e38-9.
doi: 10.2337/dc14-2124.

Remission of severe neonatal diabetes with very early sulfonylurea treatment

Bess A Marshall  1 , Rebecca P Green  2 , Jennifer Wambach  3 , Neil H White  3 , Maria S Remedi  4 , Colin G Nichols  4
Affiliations
Case Reports

Remission of severe neonatal diabetes with very early sulfonylurea treatment

Bess A Marshall et al. Diabetes Care. 2015 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A: Hemoglobin A1c (% and mmol/mol) in Case-1-male (squares) and Case-1-female (triangles) and glyburide dose (mg/kg/12 h) of Case-1-male (circles) during the months of age indicated. The asterisk and cross mark the age at which glyburide was initiated in Case-1-male and Case-1-female, respectively. B: Dose of glyburide (mg/kg/12 h) and plasma glucose (mmol/L) in the first 11 days of life in Case 2. The highest plasma glucose concentration of each day is shown by the circles, the lowest by the triangles. C: Glyburide dose (mg/kg/12 h), intravenous insulin infusion rate (U/kg/h), intravenous glucose infusion rate (mg/kg/min), and plasma glucose (mmol/L) in the first 130 days of life of Case 3 (circles are highest plasma glucose concentration per day, triangles are lowest).
See this image and copyright information in PMC

References

    1. Gloyn AL, Cummings EA, Edghill EL, et al. Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab 2004;89:3932–3935 - PubMed
    1. Karges B, Meissner T, Icks A, Kapellen T, Holl RW. Management of diabetes mellitus in infants. Nat Rev Endocrinol 2012;8:201–211 - PubMed
    1. Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG. Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation. Pediatr Diabetes 2010;11:286–288 - PMC - PubMed
    1. Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG. Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes. Diabetes 2011;60:2515–2522 - PMC - PubMed
    1. Khurana D, Contreras M, Malhotra N, Bargman R. The diagnosis of neonatal diabetes in a mother at 25 years of age. Diabetes Care 2012;35:e59. - PMC - PubMed