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. 1989 Aug;5(2):204-8.
doi: 10.1016/0888-7543(89)90047-5.

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M Litt  1 , J Luty, M Kwak, L Allen, R E Magenis, G Mandel
Affiliations

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M Litt et al. Genomics. 1989 Aug.

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

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