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. 2015;25(3):239-45.
doi: 10.2188/jea.JE20140089. Epub 2015 Feb 7.

Descriptive epidemiology of Kawasaki disease in Japan, 2011-2012: from the results of the 22nd nationwide survey

Nobuko Makino  1 , Yosikazu Nakamura, Mayumi Yashiro, Ryusuke Ae, Satoshi Tsuboi, Yasuko Aoyama, Takao Kojo, Ritei Uehara, Kazuhiko Kotani, Hiroshi Yanagawa
Affiliations

Descriptive epidemiology of Kawasaki disease in Japan, 2011-2012: from the results of the 22nd nationwide survey

Nobuko Makino et al. J Epidemiol. 2015.

Abstract
in English, Japanese

Background: The number of patients and incidence rate of Kawasaki disease (KD) are increasing in Japan. We have therefore characterized the latest epidemiological information on KD.

Methods: The 22nd nationwide survey of KD, which targeted patients diagnosed with KD in 2011 and 2012, was conducted in 2013 and included a total of 1983 departments and hospitals. In order to report on all patients with KD during the 2 survey years, we targeted hospitals of 100 beds or more with pediatric departments, or specialized pediatric hospitals.

Results: From a total of 1420 hospitals and departments (71.6% response rate), 26,691 KD patients were reported (12,774 in 2011 and 13,917 in 2012; 15,442 males and 11,249 females). The annual incidence rates were 243.1 per 100,000 population aged 0 to 4 years in 2011 and 264.8 in 2012. The number of cases of KD recorded in 2012 was the highest ever reported in Japan. The incidence rate of complete cases was also the highest ever reported in Japan and contributed to the increase in the rate of total cases in recent years. The number of patients diagnosed per month peaked in January, and additional peaks were noted during summer months, although these peaks were lower than those seen in winter. Age-specific incidence rate showed a monomodal distribution with a peak in the latter half of the year in which patients were born.

Conclusions: The number of patients and the incidence rate of KD in Japan continue to increase. A similar trend has also been seen for patients with complete KD.

背景：: 日本では川崎病の患者数、罹患率ともに増加の一途をたどっている。今回、川崎病の最新の疫学データを解析した。

方法：: 第22回川崎病全国調査を2013年に行った。2011年および2012年に川崎病を診断した1983施設を対象とした。小児科を標榜する100床以上の病院、および小児病院を対象とし、２年間の調査期間中に川崎病と診断されたすべての患者の報告を求めた。

結果：: 1420施設(回収率71.6%)から, 26,691人(2011年12,774人、2012年13,917人)の川崎病患者が報告された。男15,442人、女11,249人であった。0-4歳人口10万対罹患率は2011年243.1、2012年264.8であり、2012年の患者数は日本で報告されたものの中では最高であった。2012年の定型例の罹患率も日本で報告されたものの中で最高であり、近年の罹患率の増加に寄与した。月別推移では1月に患者数のピークがあり、夏にも1月に比べると低いピークがあった。年齢別罹患率では月齢6か月以内にピークを持つ一峰性の分布が見られた。

結論：: 川崎病の患者数および罹患率は日本においては増加し続けている。定型例においても同様の傾向が認められた。

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Figures

Figure 1.
Figure 1.. Number of patients with Kawasaki disease in Japan, by calendar year and sex
Figure 2.
Figure 2.. Incidence rate of Kawasaki disease in Japan, by calendar year and sex
Figure 3.
Figure 3.. Incidence rate of complete Kawasaki disease in Japan, by calendar year and sex
Figure 4.
Figure 4.. Number of patients with Kawasaki disease in Japan from 2001 through 2012, by month and sex
Figure 5.
Figure 5.. Age-specific incidence rate of Kawasaki disease from 2011 through 2012, by sex
See this image and copyright information in PMC

References

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