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. 2015 Feb 25;18(7):pyv014.
doi: 10.1093/ijnp/pyv014.

Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of healthy nonobese humans

Fernando Caravaggio  1 , Carol Borlido  1 , Margaret Hahn  1 , Zhe Feng  1 , Gagan Fervaha  1 , Philip Gerretsen  1 , Shinichiro Nakajima  1 , Eric Plitman  1 , Jun Ku Chung  1 , Yusuke Iwata  1 , Alan Wilson  1 , Gary Remington  1 , Ariel Graff-Guerrero  2
Affiliations

Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of healthy nonobese humans

Fernando Caravaggio et al. Int J Neuropsychopharmacol. .

Abstract

Background: Food addiction is a debated topic in neuroscience. Evidence suggests diabetes is related to reduced basal dopamine levels in the nucleus accumbens, similar to persons with drug addiction. It is unknown whether insulin sensitivity is related to endogenous dopamine levels in the ventral striatum of humans. We examined this using the agonist dopamine D2/3 receptor radiotracer [(11)C]-(+)-PHNO and an acute dopamine depletion challenge. In a separate sample of healthy persons, we examined whether dopamine depletion could alter insulin sensitivity.

Methods: Insulin sensitivity was estimated for each subject from fasting plasma glucose and insulin using the Homeostasis Model Assessment II. Eleven healthy nonobese and nondiabetic persons (3 female) provided a baseline [(11)C]-(+)-PHNO scan, 9 of which provided a scan under dopamine depletion, allowing estimates of endogenous dopamine at dopamine D2/3 receptor. Dopamine depletion was achieved via alpha-methyl-para-tyrosine (64mg/kg, P.O.). In 25 healthy persons (9 female), fasting plasma and glucose was acquired before and after dopamine depletion.

Results: Endogenous dopamine at ventral striatum dopamine D2/3 receptor was positively correlated with insulin sensitivity (r(7)=.84, P=.005) and negatively correlated with insulin levels (r(7)=-.85, P=.004). Glucose levels were not correlated with endogenous dopamine at ventral striatum dopamine D2/3 receptor (r(7)=-.49, P=.18). Consistently, acute dopamine depletion in healthy persons significantly decreased insulin sensitivity (t(24)=2.82, P=.01), increased insulin levels (t(24)=-2.62, P=.01), and did not change glucose levels (t(24)=-0.93, P=.36).

Conclusion: In healthy individuals, diminished insulin sensitivity is related to less endogenous dopamine at dopamine D2/3 receptor in the ventral striatum. Moreover, acute dopamine depletion reduces insulin sensitivity. These findings may have important implications for neuropsychiatric populations with metabolic abnormalities.

Keywords: D2; diabetes; dopamine; glucose; insulin.

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Figures

Figure 1.
Figure 1.
Relationship between estimated insulin sensitivity (IS) and endogenous dopamine at D2/3 receptors (D2/3R) in the ventral striatum (VS) of 9 healthy persons.
Figure 2.
Figure 2.
Relationship between baseline dopamine D2/3 receptor (D2/3R) availability – [11C]-(+)-PHNO BPND – and estimated insulin sensitivity (IS) in 11 healthy persons.
Figure 3.
Figure 3.
Effect of acute dopamine depletion via alpha-methyl-para-tyrosine (AMPT) on estimated insulin sensitivity (IS), and fasting plasma levels of insulin and glucose, in 25 healthy persons (error bars represent SD). For 8 subjects, their post depletion IS values went against the general trend: 6 increased and 2 remained the same.
See this image and copyright information in PMC

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