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Case Reports
. 2015 Feb 21;21(7):2210-3.
doi: 10.3748/wjg.v21.i7.2210.

Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features

Marino E Leon  1 , Rania Shamekh  1 , Domenico Coppola  1
Affiliations
Case Reports

Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features

Marino E Leon et al. World J Gastroenterol. .

Abstract

Human papillomavirus (HPV) related squamous cell carcinoma (SCC) involving the anal canal is a well-known carcinoma associated with high-risk types of HPV. HPV-related SCC with papillary morphology (papillary SCC) has been described in the oropharynx. We describe, for the first time, a case of anal HPV-related squamous carcinoma with papillary morphology. The tumor arose from the anal mucosa. The biopsies revealed a superficially invasive SCC with prominent papillary features and associated in situ carcinoma. The tumor cells were positive for p16 and were also positive for high-risk types of HPV using chromogenic in situ hybridization. The findings are consistent with a HPV-related SCC of the anal canal with papillary features. This tumor shows histologic features similar to a papillary HPV-related SCC of the oropharynx. Additional studies are needed to characterize these lesions.

Keywords: Anus; Carcinoma in situ; Human papillomavirus; Papillary; Squamous cell carcinoma.

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Figures

Figure 1
Figure 1
Biopsy of anal mass showing a squamous cell carcinoma with prominent papillary features (HE, × 100).
Figure 2
Figure 2
Higher power view of the papillary structures and associated anal intraepithelial neoplasia 3 (carcinoma-situ) (HE, × 200).
Figure 3
Figure 3
p-16 immunohistochemical stain showing strong and diffuse positive reaction of the tumor cells (× 100).
Figure 4
Figure 4
In-situ hybridization for high risk types of human papillomavirus showing a strong and diffuse reaction of the epithelial tumor cells (× 200).
See this image and copyright information in PMC

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