PQQ, the elusive coenzyme
- PMID: 2572081
- DOI: 10.1016/0968-0004(89)90169-2
PQQ, the elusive coenzyme
Abstract
The recently discovered redox coenzyme, PQQ (methoxatin), is widely distributed. Quantitation of protein-bound PQQ has been difficult, but unique redox cycling reactions, which reflect its striking biological properties, reveal trace amounts. PQQ is a potential target for drugs.
Comment in
-
PQQ, an elusive coenzyme?Trends Biochem Sci. 1990 Mar;15(3):96-7. doi: 10.1016/0968-0004(90)90189-i. Trends Biochem Sci. 1990. PMID: 2158157 No abstract available.
Similar articles
-
Methoxatin (PQQ), coenzyme for copper-dependent amine and mixed-function oxidation in mammalian tissues.Connect Tissue Res. 1989;20(1-4):251-7. doi: 10.3109/03008208909023895. Connect Tissue Res. 1989. PMID: 2558842 Review.
-
Inhibition of redox cycling of methoxatin (PQQ), and of superoxide release by phagocytic white cells.Free Radic Biol Med. 1995 Mar;18(3):617-20. doi: 10.1016/0891-5849(94)00178-m. Free Radic Biol Med. 1995. PMID: 9101256
-
The redox-cycling assay is not suited for the detection of pyrroloquinoline quinone in biological samples.FEBS Lett. 1990 Feb 12;261(1):131-4. doi: 10.1016/0014-5793(90)80653-z. FEBS Lett. 1990. PMID: 2155129
-
Protein lysine 6-oxidase (lysyl oxidase) cofactor: methoxatin (PQQ) or pyridoxal?Int J Biochem. 1988;20(12):1451-6. doi: 10.1016/s0020-711x(98)90015-5. Int J Biochem. 1988. PMID: 2468539
-
Wither PQQ.Essays Biochem. 1992;27:119-34. Essays Biochem. 1992. PMID: 1330543 Review. No abstract available.
Cited by
-
The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc.Front Neurosci. 2020 Jul 24;14:778. doi: 10.3389/fnins.2020.00778. eCollection 2020. Front Neurosci. 2020. PMID: 32792905 Free PMC article. Review.
-
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.J Biol Chem. 2010 Jan 1;285(1):142-52. doi: 10.1074/jbc.M109.030130. Epub 2009 Oct 27. J Biol Chem. 2010. PMID: 19861415 Free PMC article.
-
Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway.J Am Chem Soc. 2019 Mar 13;141(10):4398-4405. doi: 10.1021/jacs.8b13453. Epub 2019 Feb 27. J Am Chem Soc. 2019. PMID: 30811189 Free PMC article.
-
Supplementation of PQQ from pregnancy prevents MK-801-induced schizophrenia-like behaviors in mice.Psychopharmacology (Berl). 2022 Jul;239(7):2263-2275. doi: 10.1007/s00213-022-06113-9. Epub 2022 Mar 16. Psychopharmacology (Berl). 2022. PMID: 35294602
-
The neuroprotective effect of pyrroloquinoline quinone on traumatic brain injury.J Neurotrauma. 2012 Mar 20;29(5):851-64. doi: 10.1089/neu.2011.1882. Epub 2011 Dec 20. J Neurotrauma. 2012. PMID: 22040225 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources