Merlin's wizardry guides cohesive migration
- PMID: 25720961
- DOI: 10.1038/ncb3126
Merlin's wizardry guides cohesive migration
Abstract
Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and the Rac1 small GTPase.
Comment on
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A molecular mechanotransduction pathway regulates collective migration of epithelial cells.Nat Cell Biol. 2015 Mar;17(3):276-87. doi: 10.1038/ncb3115. Epub 2015 Feb 23. Nat Cell Biol. 2015. PMID: 25706233
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