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Review
. 2015 Apr;1855(2):183-92.
doi: 10.1016/j.bbcan.2015.02.002. Epub 2015 Feb 23.

Transcription factors and chromatin proteins as therapeutic targets in cancer

Simon J Johnston  1 , Jason S Carroll  2
Affiliations
Review

Transcription factors and chromatin proteins as therapeutic targets in cancer

Simon J Johnston et al. Biochim Biophys Acta. 2015 Apr.

Abstract

Targeting the factors that regulate gene transcription is a compelling strategy in cancer therapeutics. Traditionally, these have been considered intractable targets, but recent work has revealed novel strategies for the regulation of transcription factor activity in cancer. This review will highlight some of the emerging concepts and provide examples where agents that target transcription factors are being exploited clinically for cancer therapies.

Keywords: Cancer; Drugs; Nuclear receptors; Small molecules; Transcription factors; siRNA.

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