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Meta-Analysis
. 2015 Feb 27;2015(2):CD003712.
doi: 10.1002/14651858.CD003712.pub3.

Transmyocardial laser revascularization versus medical therapy for refractory angina

Eduardo Briones  1 , Juan Ramon Lacalle, Ignacio Marin-Leon, José-Ramón Rueda
Affiliations
Meta-Analysis

Transmyocardial laser revascularization versus medical therapy for refractory angina

Eduardo Briones et al. Cochrane Database Syst Rev. .

Abstract

Background: This is an update of a review previously published in 2009. Chronic angina and advanced forms of coronary disease are increasingly more frequent. In spite of the improvement in the efficacy of available revascularization treatments, a subgroup of patients continue suffering from refractory angina. Transmyocardial laser revascularization (TMLR) has been proposed to improve the clinical situation of these patients.

Objectives: To assess the effects (both benefits and harms) of TMLR versus optimal medical treatment in people with refractory angina who are not candidates for percutaneous coronary angioplasty or coronary artery bypass graft, in alleviating angina severity, reducing mortality and improving ejection fraction.

Search methods: We searched the following resources up to June 2014: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, the metaRegister of Controlled Trials database, ClinicalTrials.gov, and the WHO International Clinical Trials Registry. We applied no languages restrictions. We also checked reference lists of relevant papers.

Selection criteria: We selected studies if they fulfilled the following criteria: randomized controlled trials (RCTs) of TMLR, by thoracotomy, in patients with Canadian Cardiovascular Society or New York Heart Association angina grade III-IV who were excluded from other revascularization procedures.

Data collection and analysis: Three authors independently extracted data for each trial about the population and interventions compared and assessed the risk of bias of the studies, evaluating randomisation sequence generation, allocation concealment, blinding (of participants, personnel and outcome assessors), incomplete outcome data, selective outcome reporting, and other potential sources of bias.

Main results: From a total of 502 references, we retrieved 47 papers for more detailed evaluation. We selected 20 papers, reporting data from seven studies, which included 1137 participants, of which 559 were randomized to TMLR. Participants and professionals were not blinded, which suggests high risk of performance bias. Overall, 43.8% of participants in the treatment group decreased two angina classes, as compared with 14.8% in the control group: odds ratio (OR) 4.63, 95% confidence interval (CI) 3.43 to 6.25), and heterogeneity was present. Mortality by intention-to-treat analysis was similar in both groups at 30 days (4.0% in the TMLR group and 3.5% in the control group), and one year (12.2% in the TMLR group and 11.9% in the control group). However, the 30-day mortality as-treated was 6.8% in the TMLR group and 0.8% in the control group (pooled OR was 3.76, 95% CI 1.63 to 8.66), mainly due to a higher mortality in participants crossing from standard treatment to TMLR. The assessment of subjective outcomes, such as improvement in angina, was affected by a high risk of bias and this may explain the differences found. Other adverse events such as myocardial infarction, arrhythmias or heart failure, were not considered in this review, as they were not predefined outcomes in trials design and they show a high inconsistency across studies. No new trials on transmyocardial laser revascularization have been published in the last ten years and it is very unlikely that new research will be undertaken in this field.

Authors' conclusions: This review shows that risks associated with TMLR outweigh the potential clinical benefits. Subjective outcomes are subject to high risk of bias and no differences were found in survival, but a significant increase in postoperative mortality and other safety outcomes suggests that the procedure may pose unacceptable risks.

PubMed Disclaimer

Conflict of interest statement

None known.

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 1 Angina reduction.
1.2
1.2. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 2 Angina reduction (as‐treated).
1.3
1.3. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 3 Overall mortality.
1.4
1.4. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 4 Overall mortality (as‐treated).
1.5
1.5. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 5 Early post‐operative mortality.
1.6
1.6. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 6 Early post‐operative mortality (as‐treated).
1.7
1.7. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 7 Exercise tolerance.
1.8
1.8. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 8 Seattle Angina Questionnaire ‐ physical limitation.
1.9
1.9. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 9 Seattle Angina Questionnaire ‐ angina frequency.
1.10
1.10. Analysis
Comparison 1 Transmyocardial laser revascularization versus medical treatment, Outcome 10 Seattle Angina Questionnaire ‐ quality of life.
See this image and copyright information in PMC

Update of

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References to other published versions of this review

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