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Editorial
. 2015 Feb 27;116(5):764-6.
doi: 10.1161/CIRCRESAHA.115.306036.

SORTILIN: many headed hydra

Marit Westerterp  1 , Alan R Tall  2
Affiliations
Editorial

SORTILIN: many headed hydra

Marit Westerterp et al. Circ Res. .
No abstract available

Keywords: Editorials; LDL; atherosclerosis; foam cells; macrophages.

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Figures

Figure
Figure. SORTILIN regulates ApoB and VLDL secretion by the liver and LDL uptake in the liver and macrophages
In the basal state, hepatic SORTILIN is cleaved in the Golgi and then acts as a chaperone for VLDL/apoB secretion. At higher levels of expression, the cleavage capacity of the enzymes in the Golgi is exceeded, and SORTILIN transports VLDL/apoB from the Golgi to the lysosome for degradation. In plasma, VLDL is converted into LDL by lipoprotein lipase (LPL). SORTILIN also facilitates the uptake of LDL and targets it for lysosomal degradation in the liver. A new study shows SORTILIN facilitates LDL uptake by macrophages in the vessel wall, promoting foam cell formation and atherosclerosis.
See this image and copyright information in PMC

Comment on

References

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