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Comment
. 2015 Feb 26;160(5):807-809.
doi: 10.1016/j.cell.2015.02.027.

For longevity, perception is everything

Vanisha Lakhina  1 , Coleen T Murphy  2
Affiliations
Comment

For longevity, perception is everything

Vanisha Lakhina et al. Cell. .

Abstract

Aging is a risk factor for chronic diseases, and identifying targets for intervention is a goal of the aging field. Burkewitz et al. now describe a mechanism that mediates the specific role for AMPK in longevity, whereby its activity in neurons modulates metabolism and mitochondrial integrity in peripheral tissues.

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Figures

Figure 1.
Figure 1.. Nutrient Status Sensing in Neurons by AMPK May Relay a Signal between Neurons to Peripheral Tissues
(Top) Upon reduced AMPK activity in neurons, CRTC-1 induces octopamine secretion, which alters metabolic gene expression and causes mitochondrial fragmentation in peripheral tissues, potentially due to the transcriptional activity of DAF-16/PQM-1 within these tissues. Octopamine is most likely sensed by intermediate neurons, which may signal to peripheral cells via secreted cues such as insulins. (Bottom) AMPK/CRTC1 in the human brain may communicate via (nor)epinephrine to the intestine and peripheral tissues to regulate the pro-longevity factors, such as FOXO.
See this image and copyright information in PMC

Comment on

References

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    1. Lakhina V, Arey RN, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, and Murphy CT (2015). Neuron 85, 330–345. - PMC - PubMed
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