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Review
. 2015 Apr 1:184:244-250.
doi: 10.1016/j.ijcard.2014.11.002. Epub 2014 Nov 4.

Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives

Irene Santos-Pardo  1 , Roger Villuendas  1 , Iñaki Salvador-Corres  2 , Melania Martínez-Morillo  3 , Alejandro Olivé  4 , Antoni Bayes-Genis  5
Affiliations
Review

Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives

Irene Santos-Pardo et al. Int J Cardiol. .

Abstract

Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.

Keywords: Anti-Ro/SSA; Cardiac rhythm disturbances; Pathogenesis.

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