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Review
. 2015 Mar;102(3):270-6.
doi: 10.1016/j.bulcan.2015.01.007. Epub 2015 Feb 25.

[Is Herceptin(®) (trastuzumab) by subcutaneous a mini revolution? Pharmaco-economic study]

[Article in French]
Vincent Lieutenant  1 , Émilie Toulza  2 , Martine Pommier  2 , Barbara Lortal-Canguilhem  2
Affiliations
Review

[Is Herceptin(®) (trastuzumab) by subcutaneous a mini revolution? Pharmaco-economic study]

[Article in French]
Vincent Lieutenant et al. Bull Cancer. 2015 Mar.

Abstract

Herceptin(®) injected by intravenous (IV) is one of the key treatment of breast cancer HER2+. The improvement of galenic form allowed a new way of administration, the sub-cutaneous way (SC), authorized by EMEA in 2013. This new way enables a 5-minute infusion, a fixed dose and a fixed volume of preparation. On 2012, saving-time and financial impacts were calculated by extrapolation of the IV way in a cancer treatment center. The study showed a preparing time-saving of 7.5min/loading dose and of 6.5min/maintenance dose, and a nurse time-saving of 4.5min/loading dose and 4.25min/maintenance dose. Moreover, it can be added a saving of consumable of 13,31€ per injection in case of monotherapy. The SC leads to a new adaptation and reorganization in the preparation of monoclonal antibodies and day hospitals.

Keywords: Herceptin; Pharmaco-economic; Pharmaco-économique; Sous-cutanée; Subcutaneous.

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