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Review
. 2015 Mar;53(2):413-23.
doi: 10.1016/j.rcl.2014.11.005. Epub 2014 Dec 18.

Tissue characterization of the myocardium: state of the art characterization by magnetic resonance and computed tomography imaging

Puskar Pattanayak  1 , David A Bleumke  2
Affiliations
Review

Tissue characterization of the myocardium: state of the art characterization by magnetic resonance and computed tomography imaging

Puskar Pattanayak et al. Radiol Clin North Am. 2015 Mar.

Abstract

Late gadolinium enhancement (LGE) is a simple, robust, well-validated method for assessing scar in acute and chronic myocardial infarction. LGE is useful for distinguishing between ischemic and nonischemic cardiomyopathy. Specific LGE patterns are seen in nonischemic cardiomyopathy. Patient studies using T1 mapping have varied in study, design, and acquisition sequences. Despite the differences in technique, a clear pattern that has been seen is that in cardiac disease postcontrast T1 times are shorter. Extracellular volume fraction measured with cardiac computed tomography represents a new approach to the clinical assessment of diffuse myocardial fibrosis by evaluating the distribution of iodinated contrast.

Keywords: Characterization; Computed tomography; Extracellular volume fraction; Late gadolinium enhancement; Magnetic resonance; Myocardium; T1 mapping.

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Figures

Figure 1
Figure 1
Inferior wall MI (black arrow). Wall thinning and Late Gadolinium Enhancement is seen.
Figure 2
Figure 2
Delayed post contrast image showing LGE (black arrow) at the inferior right ventricular insertion point in a patient with hypertrophic cardiomyopathy.
Figure 3
Figure 3
Grey scale images of pre-contrast (left) and 25 min post contrast (right) T1 maps in a healthy volunteer acquired using the SMOLLI technique.
None
Cardiac MR imaging region of interest measurements obtained, A, before and, B, after gadolinium chelate administration and reformatted cardiac CT region of interest measurements obtained, C, before and, D, after administration of an iodinated contrast agent. Orange outline = myocardium, white circle = blood pool. From: Nacif et al (2012) Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT.
See this image and copyright information in PMC

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