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. 1989 Nov 4;2(8671):1063-5.
doi: 10.1016/s0140-6736(89)91079-9.

Association between susceptibility to pre-eclampsia within families and HLA DR4

D C Kilpatrick  1 , W A Liston, F Gibson, J Livingstone
Affiliations

Association between susceptibility to pre-eclampsia within families and HLA DR4

D C Kilpatrick et al. Lancet. .

Abstract

56 women who had had proteinuric pre-eclampsia and who had parous sisters were studied. In first pregnancy, proteinuric pre-eclampsia was more common in the sisters than in the maternity hospital population (8/71 [11%] vs 41/1978 [2%]); the relative risk was 6.0. The frequency of HLA DR4 was higher in sisters with pregnancy-induced hypertension than in sisters with normotensive pregnancies (8/18 [44%] vs 10/54 [19%]) and more of them shared HLA DR4 with their spouses (4/14 [29%] vs 0/29). Genetic susceptibility to pre-eclampsia is associated with HLA DR4; it may be conferred by fetomaternal sharing of a single recessive HLA-linked gene.

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Comment in

  • Association between risk for pre-eclampsia and HLA DR4.
    Hoff C, Stevens RG, Mendenhall H, Peterson RD, Spinnato JA. Hoff C, et al. Lancet. 1990 Mar 17;335(8690):660-1. doi: 10.1016/0140-6736(90)90447-d. Lancet. 1990. PMID: 1969035 No abstract available.
  • HLA-DR and pre-eclampsia in Edinburgh.
    Hayward C, Gilfillan A, Livingstone J, Adam M, McIntosh I, Brock DJ, Liston WA. Hayward C, et al. Lancet. 1990 Jun 16;335(8703):1458-9. doi: 10.1016/0140-6736(90)91483-q. Lancet. 1990. PMID: 1972227 No abstract available.

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