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. 1989 Nov 11;2(8672):1115-8.
doi: 10.1016/s0140-6736(89)91487-6.

Cathepsin D: an independent prognostic factor for metastasis of breast cancer

F Spyratos  1 , T Maudelonde, J P Brouillet, M Brunet, A Defrenne, C Andrieu, K Hacene, A Desplaces, J Rouëssé, H Rochefort
Affiliations

Cathepsin D: an independent prognostic factor for metastasis of breast cancer

F Spyratos et al. Lancet. .

Abstract

122 patients with primary breast cancer were followed-up for a median of 4.6 years after surgery. The concentration of cathepsin D in tumour cytosol was strongly related to both metastasis-free survival and disease-free survival and was independent of nine conventional prognostic indices. Cathepsin D assay may prove particularly useful in identifying women who, though without lymph node involvement at presentation, are at high risk of metastatic disease.

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