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Multicenter Study
. 2015 Jun;17(6):477-84.
doi: 10.1111/hpb.12386. Epub 2015 Feb 28.

Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis

Kristopher P Croome  1   2 , Roberto Hernandez-Alejandro  3 , Maile Parker  1 , Julie Heimbach  4 , Charles Rosen  4 , David M Nagorney  1
Affiliations
Multicenter Study

Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis

Kristopher P Croome et al. HPB (Oxford). 2015 Jun.

Abstract

Background: The clinical perspective on hepatic growth is limited. The goal of the present study was to compare hepatic hypertrophy and the kinetic growth rate(KGR) in patients after the ALPPS (Associating Liver Partition with Portal Vein Ligation for Staged Hepatectomy) procedure, portal vein embolization (PVE) and living donor liver transplantation.

Methods: Volumetry and KGR of the future liver remnant (FLR) were compared from (15) patients undergoing ALPPS, (53) patients undergoing PVE, (90) recipients of living donor liver grafts and (93) donors of living donor liver grafts.

Results: The degree of hypertrophy was significantly greater after ALPPS (84.3 ± 7.8%) than after PVE (36.0 ± 27.2%) (P < 0.001). The KGR was also significantly greater for ALPPS [32.7 ± 13.6 cubic centimetres (cc)/day] (10.8 ± 4.5%/day) compared with PVE (4.4 ± 3.2 cc/day) (0.98 ± 0.75%/day) (P < 0.001). The FLR of living donor donors had the greatest degree of hypertrophy (107.5 ± 39.2%) and was greater than after ALPPS (P = 0.02), PVE (P < 0.001) and in living donor-recipient grafts (P < 0.001). KGR (cc/day) was greater in FLR of living donor donors compared with both ALPPS (P < 0.001) and PVE (P < 0.001). The KGR in patients undergoing ALPPS and living donor liver transplantation had a linear relationship with the size of FLR.

Conclusion: FLR hypertrophy and KGR were greater after ALPPS than PVE. However, the degree of hypertrophy after ALPPS is not unprecedented, as KGR in the FLR from living donor donors is equal to or greater than after ALPPS. The KGR of the FLR in patients after ALPPS and living donor donors correlates directly with the size of the FLR.

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Figures

Figure 1
Figure 1
Extrapolation of kinetic growth of standardized future liver remnant (sFLR) volumes determined by volumetry prior to and after intervention in the four groups: a) ALPPS, b) portal vein embolization (PVE), c) living donor donors and d) living-donor recipients
Figure 2
Figure 2
The kinetic growth rate (KGR) (%/day) plotted versus pre-intervention standardized future liver remnant (sFLR) size in the ALPPS, portal vein embolization (PVE), living donor donor and living donor recipient groups. Inverse linear relationship between pre-intervention sFLR volume and KGR (P < 0.001)
Figure 3
Figure 3
Kinetic growth rate (cc/day) plotted versus pre-intervention standardized future liver remnant (sFLR) volume in the ALPPS, living donor donor and living donor recipient groups
See this image and copyright information in PMC

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