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. 2015 Mar;14(1):67-80.
doi: 10.1007/s12663-013-0605-5. Epub 2014 Jan 9.

Clinical evaluation of use of platelet rich plasma in bone healing

Kailas T Gawai  1 , C R Sobhana  2
Affiliations

Clinical evaluation of use of platelet rich plasma in bone healing

Kailas T Gawai et al. J Maxillofac Oral Surg. 2015 Mar.

Abstract

Background: Tooth extraction is performed for a wide variety of reasons as we know. Several techniques aiming at enhancing the regeneration process in the extraction socket have been adopted such as filling the socket with autogenous bone grafts or bone substitutes. We know platelets play a central role in hemostasis and healing processes but relative contradictory effect of platelet in bone regenerating capacity have been published in different in vitro and in vivo studies.

Method: To explore this we used platelet-rich plasma (PRP) (autogenous) alone in empty extraction socket of bilateral impacted mandibular third molars. For that we selected five patients having bilateral impacted teeth. Out of two sockets one was used as intervention by filling with PRP and the other was allowed to heal without PRP. All patients were followed for clinical and radiological evaluation by using digital OPG view after 1 week, 1, 2 and 4 months period.

Result and conclusion: PRP enhanced the osteogenic response in initial bone healing at 1 month duration but there was no added benefit in late bone healing at 4 months period compared in both intervention and control groups. However PRP significantly improved the soft tissue healing in PRP treated sites compared to control group.

Keywords: Early and late bone healing; Extraction socket; Platelet-rich plasma (PRP).

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Figures

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Centrifugation machine
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Armamentarium for PRP preparation
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Armamantarium for tooth extraction
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Withdrawing of blood
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First spin centrifugation
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Paltelet poor plasma and platelet rich plasma after second spin centrifugation
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Platelet rich plasma gel
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Bilateral 3rd molars removed, PRP placed to 38
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Panoromic views: PRP applied to left 3rd molar socket
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Total platelet count in whole blood and PRP
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Total platelet count with mean and standard deviation
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Wound healing at 1 week visit
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Bone density after 1 week in intervention group
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Bone density after 1 week in control group
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Bone density after 4 weeks in intervention group
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Bone density after 4 weeks in control group
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Bone density after 8 weeks in intervention group
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Bone density after 8 weeks in control group
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Bone density after 16 weeks in intervention group
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Bone density after 16 weeks in control group
See this image and copyright information in PMC

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