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. 2014 Oct;17(10):808-14.

Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats

Akram Ahangarpour  1 , Hossein Teymuri Zamaneh  2 , Ayob Jabari  3 , Hamid Malekshahi Nia  4 , Hamid Heidari  5
Affiliations

Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats

Akram Ahangarpour et al. Iran J Basic Med Sci. 2014 Oct.

Abstract

Objectives: The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats.

Materials and methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D. aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for 4 weeks. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed.

Results: D. aucheri has highly significant blood glucose lowering effect. Administration of the extract to diabetic rats resulted in a remarkable change in serum lipid profiles, insulin and leptin levels relative to diabetic group. Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats.

Conclusion: D. aucheri could be useful in treatment of diabetes. Moderate dose of D. aucheri (200 mg/kg) was more effective than the others.

Keywords: Diabetes; Dorema aucheri; Insulin; Nicotinamide; Streptozotocin.

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Figures

Figure 1.
Figure 1.
Effect of hydro-alcoholic extract of Dorema aucheri leave on body weight during 4 weeks in nicotinamide streptozotocin-induced diabetic rats b (P< 0.05) and a (P< 0.01) dia: Diabetic rat D.A 100: Dorema aucheri leave extract (100 mg/kg) D.A 200: Dorema aucheri leave extract (200 mg/kg) D.A 400: Dorema aucheri leave extract (400 mg/kg)
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