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. 2015 Apr;18(4):490-2.
doi: 10.1038/nn.3963. Epub 2015 Mar 2.

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Filippo Calzolari  1 , Julia Michel  2 , Emily Violette Baumgart  2 , Fabian Theis  3 , Magdalena Götz  4 , Jovica Ninkovic  4
Affiliations

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Filippo Calzolari et al. Nat Neurosci. 2015 Apr.

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

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References

    1. Science. 2007 Jul 20;317(5836):381-4 - PubMed
    1. Nat Neurosci. 2014 Feb;17 (2):207-14 - PubMed
    1. Nature. 2014 Mar 20;507(7492):362-365 - PubMed
    1. Trends Neurosci. 2008 Aug;31(8):392-400 - PubMed
    1. Cell Stem Cell. 2010 Dec 3;7(6):744-58 - PubMed

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